# Precision Diagnosis and Individualized Therapy of Non‐Gestational Choriocarcinoma Invading the Corpus Uteri and Cervix: A Case Report and Literature Review

## TL;DR

A rare case of non-gestational choriocarcinoma invading the uterus and cervix was accurately diagnosed and successfully treated with personalized chemotherapy.

## Contribution

This case report presents a rare instance of NGCC with dual uterine and cervical involvement confirmed by STR analysis.

## Key findings

- NGCC was initially misdiagnosed as gestational choriocarcinoma but confirmed via STR analysis.
- EMA-CO chemotherapy successfully managed the disease after surgical intervention.
- The patient's human chorionic gonadotropin levels normalized at follow-up.

## Abstract

Non‐gestational choriocarcinoma (NGCC) is a rare type of malignant tumor. Primary lesions are typically detected in the ovary and rarely invade the corpus uteri and cervix. NGCC usually has a poor prognosis due to the difficulty in achieving early and accurate diagnoses because of its rarity.

This case described a female who was initially diagnosed with gestational choriocarcinoma and treated with EMA‐CO chemotherapy. However, subsequent short tandem repeat (STR) analysis confirmed the diagnosis as NGCC, prompting surgical intervention. Given her favorable response and after thorough communication, three additional cycles of EMA‐CO chemotherapy were recommended. At her last follow‐up, her human chorionic gonadotropin level had normalized.

This case presents a rare instance of NGCC with simultaneous uterine and cervical involvement, confirmed by STR analysis and successfully managed with the EMA‐CO regime. It highlights the necessity of precise diagnosis and personalized treatment for effective management of this disease.