# Gastrohepatic Fistula Secondary to Metastatic Colorectal Adenocarcinoma in a Patient With Lynch Syndrome

**Authors:** Abdulla Alabed, Faisal Abubaker, Ahmed Daibes, Sarah Altamimi

PMC · DOI: 10.1016/j.gastha.2025.100807 · Gastro Hep Advances · 2025-09-14

## TL;DR

This paper reports a rare case of a stomach-to-liver abnormal connection caused by advanced colorectal cancer in a patient with a genetic condition called Lynch Syndrome.

## Contribution

The novelty lies in documenting a rare complication of metastatic colorectal cancer in the context of Lynch Syndrome.

## Key findings

- A gastrohepatic fistula was identified in a patient with metastatic colorectal adenocarcinoma.
- The case highlights the importance of multidisciplinary care in managing advanced cancer complications.
- Palliative care is emphasized as an appropriate strategy when curative treatments are not feasible.

## Abstract

A gastrohepatic fistula is an abnormal connection between the stomach and the liver. It can occur in the setting of colorectal liver metastases with direct invasion into an adjacent organ, causing upper gastrointestinal bleeding. Early recognition and a multidisciplinary approach remain crucial even in advanced cases when curative options are limited; palliative care remains appropriate to guide management.

## Linked entities

- **Diseases:** Lynch Syndrome (MONDO:0005835), colorectal adenocarcinoma (MONDO:0005008)

## Full-text entities

- **Diseases:** colorectal liver metastases (MESH:D009362), upper gastrointestinal bleeding (MESH:D006471), Colorectal Adenocarcinoma (MESH:D003110), Lynch Syndrome (MESH:D003123), Gastrohepatic Fistula (MESH:D005402)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12589978/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12589978/full.md

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Source: https://tomesphere.com/paper/PMC12589978