# Chromosome-level genome assembly of Trichomonas vaginalis strain IR-78 (ATCC 50138)

## TL;DR

This paper presents a high-quality chromosome-level genome assembly of the Trichomonas vaginalis parasite, aiding research on its biology and disease mechanisms.

## Contribution

The study provides a chromosome-level genome assembly of T. vaginalis strain IR-78 using advanced sequencing technologies.

## Key findings

- The genome assembly is 173.3 Mb in size with an N50 scaffold length of 26.4 Mb.
- The assembly includes 43,326 predicted protein-coding genes, with 95.4% annotated.
- The resource supports research on pathogenesis, drug resistance, and comparative genomics in Trichomonas species.

## Abstract

Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, the most prevalent non-viral sexually transmitted infection, with significant impact on public health and economy. Here, we present a chromosome-level genome of T. vaginalis strain IR-78 (ATCC 50138), assembled using short and long-read sequencing technologies as well as chromatin conformation capture sequencing (Hi-C). The assembled genome is 173.3 Mb in size, with an N50 scaffold length of 26.4 Mb. The assembly is anchored in six super-scaffolds, corresponding to the six chromosomes of T. vaginalis, covering 93.5% of the genome. A total of 43,326 protein-coding genes were predicted, of which 95.4% were annotated using multiple databases, including Gene Ontology, eggNOG, and KEGG. Among these, 16,656 genes encoded hypothetical proteins. This high-quality genome assembly provides an additional resource for ongoing research on T. vaginalis pathogenesis, drug resistance, and host-parasite interactions. It furthermore enables comparative genomic studies to assess genomic variety across different Trichomonas species.