# QBrainNet: harnessing enhanced quantum intelligence for advanced brain stroke prediction from medical imaging

**Authors:** M. Priyadharshini, V. Murugesh, T. R. Mahesh, Eid Albalawi, Oumaima Saidani, Ali Algarni

PMC · DOI: 10.3389/fmed.2025.1677234 · Frontiers in Medicine · 2025-10-23

## TL;DR

This paper introduces QBrainNet, a quantum-enhanced model that improves brain stroke prediction from medical images with high accuracy and faster inference.

## Contribution

The novel contribution is a hybrid classical-quantum model using quantum neural networks and variational quantum circuits for stroke prediction.

## Key findings

- QBrainNet achieves 96% accuracy and 0.97 AUC-PR in stroke detection, outperforming classical models.
- The model uses quantum properties like entanglement and superposition to capture complex stroke-related patterns in images.
- QBrainNet's inference time is shorter, making it suitable for real-time clinical applications.

## Abstract

Brain stroke is still one of the leading causes of death and long-term disability in the world. Early and correct diagnosis is therefore important for patient outcome. Although Convolution Neural Network (CNN), classical machine learning models, have achieved great progress in medical image classification, they have to face the performance saturation problem when dealing with high-dimensional and complex data such as medical images. To tackle these limitations, we propose QBrainNet, a quantum enhanced model, which is to enhance brain stroke prediction from medical imaging datasets.

The model consists of Quantum Neural Networks (QNNs) applied as learning complex patterns in terms of medical images and Variational Quantum Circuits (VQCs) that will be used to optimize the classification. The feature extraction featured in the QNNs utilises quantum properties of superposition and entanglement to extract non-linear high-dimensional patterns in images related to stroke that may not be captured using classical limits. The VQCs, in turn, are applied to optimize the model performance, further allocating the boundaries of the decision and enhancing the model performance in terms of accuracy by optimizing the quantum gates and operators used during the work. QBrainNet utilizes the combination of such quantum properties as entanglement and superposition to represent more complicated non-linear patterns in stroke-specific images in a better manner than a classical application does.

This paper proposes a hybrid classical-quantum scheme: preprocessing classically, and learning quantum-enhanced. Quantum gates and operators are used when performing the quantum phase to optimize decision boundaries, achieving vastly enhanced prediction accuracy and efficiency performance. Experimental results indicate that QBrainNet has a better accuracy (96%) and AUC-PR (0.97) than the classical models like CNN, SVM, and Random Forest, proving the superior performance of QBrainNet in stroke detection.

The inference time is shorter, so the model can be used as a real-time clinical application. This article points to the possibilities quantum computing can have in revolutionizing medical diagnostics, especially stroke prediction.

## Linked entities

- **Diseases:** stroke (MONDO:0005098)

## Full-text entities

- **Diseases:** Brain stroke (MESH:D001927), death (MESH:D003643), stroke (MESH:D020521)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12589079/full.md

## Figures

17 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12589079/full.md

## References

54 references — full list in the complete paper: https://tomesphere.com/paper/PMC12589079/full.md

---
Source: https://tomesphere.com/paper/PMC12589079