# Unilateral pulmonary edema after minimally-invasive redo-double valve replacement procedure—case report

**Authors:** Dan Wang, Jia Yang, Haibo Ren

PMC · DOI: 10.3389/fcvm.2025.1662660 · Frontiers in Cardiovascular Medicine · 2025-10-23

## TL;DR

A patient developed severe lung complications after a minimally invasive heart valve surgery and was successfully treated with advanced life support.

## Contribution

Highlights the use of VV-ECMO in managing refractory respiratory failure after minimally invasive cardiac surgery.

## Key findings

- The patient developed re-expansion pulmonary edema leading to ARDS after surgery.
- VV-ECMO was crucial in supporting the patient's recovery from severe respiratory failure.
- Multidisciplinary team collaboration was essential in managing the complex case.

## Abstract

This case report describes a patient with a history of mechanical aortic and mitral valve replacements who developed prosthetic valve stenosis years later and underwent a minimally invasive, thoracoscopic-assisted double valve re-replacement. Postoperatively, the patient developed a rare but life-threatening re-expansion pulmonary edema (RPE), which led to severe acute respiratory distress syndrome (ARDS), with rapid deterioration into refractory hypoxemia. Despite comprehensive conventional supportive management—including lung-protective ventilation, diuresis, anti-inflammatory therapy, and other measures—adequate oxygenation could not be maintained. Venovenous extracorporeal membrane oxygenation (VV-ECMO) was emergently initiated. With ECMO support, the patient's lungs were able to rest and recover. After 10 days of support, ECMO was successfully discontinued, and the patient eventually recovered and was discharged. This case aims to explore the pathophysiological mechanisms of RPE, management strategies for complications following minimally invasive cardiac surgery, and to emphasize the critical role of VV-ECMO in treating refractory respiratory failure, as well as the importance of multidisciplinary team (MDT) collaboration.

## Linked entities

- **Diseases:** acute respiratory distress syndrome (MONDO:0006502)

## Full-text entities

- **Diseases:** hypoxemia (MESH:D000860), RPE (MESH:D011654), valve stenosis (MESH:D001024), ARDS (MESH:D012128), respiratory failure (MESH:D012131), inflammatory (MESH:D007249)
- **Chemicals:** Venovenous (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12589066/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12589066/full.md

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Source: https://tomesphere.com/paper/PMC12589066