# Expression and significance of PIBF combined with Galectin-1 in cervical precancerous lesions

## TL;DR

This study explores how PIBF and Galectin-1 levels change in cervical precancerous lesions and their potential role in disease progression.

## Contribution

The novel contribution is identifying elevated PIBF and Galectin-1 levels in advanced cervical dysplasia as potential markers for disease progression.

## Key findings

- PIBF and Galectin-1 levels increase significantly in CIN2 and CIN3 compared to cervicitis and CIN1.
- Higher PIBF and Galectin-1 levels correlate with the progression of cervical intraepithelial neoplasia.
- Levels in precervical lesions are significantly higher than in normal cervical tissues.

## Abstract

This study aimed to discuss the significance of PIBF and Galectin-1 in cervical dysplasia tissue.

The expression of PIBF and Galectin-1 in precancerous tissues of cervical cancer was determined by the immunohistochemical method and ELISA method, and their clinical significance was analyzed.

PIBF and Galectin-1 levels in cervicitis and CIN1 tissues showed no statistically significant difference; the levels of PIBF and Galectin-1 in CIN2 and CIN3 tissues were higher than those in cervicitis and CIN1, and the differences were statistically significant when compared with other groups in the CIN3 group.

Compared with the normal cervical lesion tissue, the levels of PIBF and Galectin-1 in the precervical lesion tissue were significantly increased, suggesting that their elevated levels are significantly associated with the progression of cervical intraepithelial neoplasia.