# Granulomatosis With Polyangiitis Manifesting With Diabetes Insipidus and Cranial Nerve Involvement: A Case Report and Review of the Literature

**Authors:** Mina Kiafar, Goharsharieh Alishiri, Ahmadreza Sadeghi, Amirreza Paksaz, Leila Khezrloo, Soheila Borji

PMC · DOI: 10.1002/ccr3.71429 · Clinical Case Reports · 2025-11-05

## TL;DR

A rare case of granulomatosis with polyangiitis presented with diabetes insipidus and cranial nerve issues, emphasizing the need for accurate diagnosis.

## Contribution

The novelty lies in presenting a rare clinical manifestation of granulomatosis with polyangiitis involving diabetes insipidus and cranial nerve palsy.

## Key findings

- Granulomatosis with polyangiitis can manifest with diabetes insipidus and cranial nerve involvement.
- Early suspicion and targeted investigations are crucial for accurate diagnosis in atypical presentations.

## Abstract

This report describes a rare case of granulomatosis with polyangiitis presenting with diabetes insipidus and third cranial nerve involvement. Given the wide range of vasculitis presentations, this case highlights the importance of considering such diagnoses in patients with diverse signs and symptoms to prevent misdiagnosis or delayed diagnosis and to utilize targeted laboratory and paraclinical studies based on clinical suspicion to achieve an accurate diagnosis.

## Linked entities

- **Diseases:** Granulomatosis with polyangiitis (MONDO:0012105), diabetes insipidus (MONDO:0004782)

## Full-text entities

- **Diseases:** Cranial Nerve (MESH:D003389), Diabetes Insipidus (MESH:D003919), vasculitis (MESH:D014657), Polyangiitis (MESH:D014890), third cranial nerve involvement (MESH:D061220), Granulomatosis (MESH:D015267)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12588874/full.md

## References

28 references — full list in the complete paper: https://tomesphere.com/paper/PMC12588874/full.md

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Source: https://tomesphere.com/paper/PMC12588874