# Inverting the logic in amyotrophic lateral sclerosis

## TL;DR

The paper suggests studying resilient individuals in ALS to shift focus from disease to resistance.

## Contribution

Proposes a novel approach to ALS research by emphasizing survivorship bias and resilience.

## Key findings

- ALS research may benefit from studying resilient individuals rather than those affected.
- Neurodegeneration involves loss of tolerance, not just gain of toxicity.

## Abstract

Turner highlights survivorship bias in the study of neurodegenerative disorders such as ALS, suggesting that meaningful progress may require a fundamental shift in focus from the affected to the resilient, and from what is seen to what is not. Neurodegeneration should be viewed as a loss of tolerance as much as a gain of toxicity.