# Better understanding of laboratory animal genetics will improve reproducibility

**Authors:** Guillaume Pavlovic, Sara Wells, Yann Hérault, Lydia Teboul

PMC · DOI: 10.1371/journal.pbio.3003464 · PLOS Biology · 2025-10-30

## TL;DR

Improving the genetic characterization and reporting of lab animals can enhance the quality and reproducibility of scientific research.

## Contribution

The paper introduces the LAG-R guidelines and advocates for collective action to improve genetic reporting standards.

## Key findings

- Incomplete genetic characterization of lab animals undermines research reproducibility.
- Implementing the LAG-R guidelines can address critical gaps in genetic reporting.
- Improved training and rigorous standards are needed to enhance scientific integrity.

## Abstract

Inconsistent characterization and reporting of laboratory animal genetics undermine research quality and reproducibility. We need to recognize the value of genetic characterization, improve training for researchers, and implement rigorous reporting standards.

Incomplete characterization and inconsistent reporting of laboratory animal genetics undermine study quality and limit research reproducibility. This Perspective highlights the LAG-R guidelines and calls for collective action to address these critical gaps and enhance scientific integrity.

## Full text

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12588450/full.md

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Source: https://tomesphere.com/paper/PMC12588450