# Epetraborole pharmacokinetics/pharmacodynamics in the hollow fiber system model of Mycobacterium tuberculosis

## TL;DR

The study finds that high doses of epetraborole may be needed to treat tuberculosis, but these doses could be unsafe for patients.

## Contribution

The study identifies an optimal exposure target for epetraborole and evaluates its dosing safety in TB treatment.

## Key findings

- An AUC0-24/MIC ratio of 327.1 is the optimal target for epetraborole against Mycobacterium tuberculosis.
- High intravenous doses of epetraborole may not be safe for most patients.
- Monte Carlo simulations suggest current dosing regimens may be ineffective for many patients.

## Abstract

In the hollow fiber system model of tuberculosis (TB), the ratio of area
under the concentration-time curve to MIC (AUC0-24/MIC) of 327.1
was identified as the epetraborole optimal exposure target for
Mycobacterium tuberculosis kill. Monte Carlo simulation
experiments showed that even the intravenous dose of 1,500 mg/twice daily
would fail in the majority of patients, and the dose needed for good
efficacy for TB may likely not be safe for patients.