# Encapsulated Papillary Carcinoma of the Male Breast: A Case Report and Literature Review

**Authors:** Kristina Anichkina, Alina Pasternak, Gurami Kvetenadze, Evgenii Shivilov, Tamara Pavlova

PMC · DOI: 10.7759/cureus.93922 · Cureus · 2025-10-06

## TL;DR

This case report highlights the difficulties in diagnosing and treating a rare type of breast cancer in men, emphasizing the need for careful surgical planning.

## Contribution

The paper presents a rare case of encapsulated papillary carcinoma in the male breast and reviews the diagnostic and treatment challenges.

## Key findings

- The tumor was confirmed as encapsulated papillary cancer through surgical and pathoanatomic examination.
- High estrogen and progesterone receptor expression led to hormone therapy with tamoxifen.
- Lack of specific diagnostic features often results in more radical surgery for this low-grade tumor.

## Abstract

This case report aims to demonstrate the challenges associated with the diagnosis and treatment of papillary carcinomas of the male breast. Based on a comprehensive screening, which included a pathoanatomic examination of the surgical material after a simple Pirogov mastectomy (a surgical procedure where all or part of a breast and axillary lymph nodes are removed), the diagnosis was confirmed as encapsulated papillary cancer of the left breast. In the immunohistochemical study, the estrogen receptor was 100%, the progesterone receptor was 90%, and Ki-67 was 60%. Therefore, the patient was prescribed adjuvant hormone therapy with tamoxifen. There are no specific diagnostic clinical, imaging, or core needle biopsy features of encapsulated papillary carcinoma of the male breast. This often leads to more radical surgery for this low-grade neoplasm. Before choosing the extent of surgery, it is necessary to consider the primary size of the tumor along with an intraoperative assessment of the resection margins.

## Linked entities

- **Chemicals:** tamoxifen (PubChem CID 2733526)
- **Diseases:** papillary carcinoma (MONDO:0006509), breast cancer (MONDO:0004989)

## Full-text entities

- **Genes:** ESR1 (estrogen receptor 1) [NCBI Gene 2099] {aka ER, ESR, ESRA, ESTRR, Era, NR3A1}, PGR (progesterone receptor) [NCBI Gene 5241] {aka NR3C3, PR}
- **Diseases:** papillary cancer of the left breast (MESH:D001943), neoplasm (MESH:D009369), Papillary Carcinoma of the Male Breast (MESH:D018567)
- **Chemicals:** tamoxifen (MESH:D013629)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12587332/full.md

## References

30 references — full list in the complete paper: https://tomesphere.com/paper/PMC12587332/full.md

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Source: https://tomesphere.com/paper/PMC12587332