Synthesis and Study of the Ru-Pt Heterometallic Complexes [RuCp(L) (PPh3)-µ-dmoPTA-1κP:2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)][PtCl4] (L = Cl, PPh3)

TL;DR

This paper reports the synthesis and characterization of new Ru-Pt heterometallic complexes and evaluates their antiproliferative activity against human tumor cells.

Contribution

The study introduces novel Ru-Pt heterometallic complexes and demonstrates their potential as antitumor agents.

Findings

Complex 1 showed submicromolar antiproliferative activity against six human solid tumor cell lines.

The crystal structure of complex 2 was determined using single crystal X-ray diffraction.

The complexes were characterized using NMR, IR, and other analytical techniques.

Abstract

Complexes [RuCp(PPh3)2(HdmoPTA)][PtCl4] (1), [RuCp(PPh3)2-µ-dmoPTA-1κP:2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)][PtCl4] (2), [RuClCp(PPh3) (HdmoPTA)]2[PtCl4] (3), and [RuClCp(PPh3)-µ-dmoPTA-1κP:2κ2-N,N′-Pt(κ2C,O-CH2N(CH3)CHO)]2[PtCl4] (4) have been synthesized and characterized by NMR, IR, and crystal structure of 2 was obtained by single crystal X-Ray diffraction. Antiproliferative activity of 1 was assessed against six human solid tumor cell lines and compared to cisplatin as a standard, showing GI50 values in the submicromolar range.

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