Integrative Approaches in Structural Science: Bridging Electron and X-ray Techniques

TL;DR

This paper discusses how combining different structural science techniques improves research capabilities at Yale University's Structural Science Facility.

Contribution

The paper introduces a unified Structural Science Facility that integrates multiple structural determination techniques for enhanced scientific outcomes.

Findings

Consolidating scattering, imaging, and diffraction resources into a unified facility enhances scientific capabilities.

Integration of MicroED, X-ray diffraction, and SAXSWAXS promotes effective interoperability among methods.

Successful workflows and best practices for maintaining collaboration among techniques are highlighted.

Abstract

Chemistry core facilities have long hosted multimodal instrumentation alongside specialized systems designed for targeted scientific inquiries. At Yale University's Chemical and Biophysical Instrumentation Center, we have strategically consolidated resources for scattering, imaging, and diffraction into a unified Structural Science Facility. My presentation will focus on the integration of complementary structural determination techniques, specifically MicroED, single-crystal X-ray diffraction, powder X-ray diffraction, and SAXSWAXS, within a cohesive ecosystem of university cores, highlighting how such consolidation enhances their collective scientific capabilities. Additionally, I'll discuss how this integrative philosophy extends to collaborations with partner cores. I will highlight use cases, successful workflows, and best practices for maintaining effective interoperability among these complementary methods.