# Nuclear Protein in Testis (NUT) Carcinoma With Nasopharyngeal and Intracranial Involvement: A Case Report

## TL;DR

This case report describes a rare and aggressive cancer called NUT carcinoma that affected a man's nasopharynx and brain, highlighting its diagnosis and treatment challenges.

## Contribution

The report adds to the limited literature on NUT carcinoma by presenting a case with nasopharyngeal and intracranial involvement.

## Key findings

- A 43-year-old male was diagnosed with NUT carcinoma involving the nasopharynx and frontal brain region.
- The case highlights the diagnostic challenges associated with NUT carcinoma due to its rarity and aggressive nature.
- The report emphasizes the importance of molecular testing for accurate diagnosis and treatment planning.

## Abstract

Nuclear protein in testis (NUT) carcinoma is a rare and aggressive malignancy characterized by NUT gene rearrangement. Previously classified as NUT midline carcinoma, this malignancy was reclassified to NUT carcinoma in order to reflect that it can occur outside midline structures of the body. This case report follows a 43-year-old male presenting with a nasopharyngeal mass invading the frontal brain region, ultimately diagnosed as NUT carcinoma. Here, we detail the clinical and molecular characteristics of this tumor to contribute to the growing body of literature on this rare malignancy, while acknowledging potential diagnostic challenges and therapeutic considerations.