# Cationic Covalent Organic Framework as Fluorescent Sensor for the Detection of Poly- and Perfluoroalkyl Substances (PFAS)

**Authors:** Maryam Piroozzadeh

PMC · DOI: 10.1063/4.0001128 · 2025-10-27

## TL;DR

A new fluorescent sensor made from a cationic covalent organic framework is developed to detect harmful PFAS chemicals in water more efficiently.

## Contribution

A novel cationic covalent organic framework is designed for the fluorescent detection of PFAS compounds.

## Key findings

- The c-COF sensor effectively detects both light-weight PFCAs and PFOS.
- The sensor offers advantages like fast response and potential for handheld devices.

## Abstract

Abstract

Sensitive detection methods for “PFAS” are critical for evaluating the safety level of our water sources. LC-MS-MS is the method currently we are using for the detection of PFAS, but it requires highly trained laboratory personnel, expensive and complex instrumentation, difficult sample preparation, and tedious data collection. Therefore, alternative detection method based on fluorescent sensing have intrinsic advantages like fast response time, easy operation, cost effectiveness, naked eye identification, and the potential to build hand-held sensor devices for onsite detection. We have designed a novel cationic covalent organic framework (c-COF) based on perylene diimide The hydrophobic functionality and cationic charge assisted for the detection of both light weight PFCAs and PFOS.

## Linked entities

- **Chemicals:** PFOS (PubChem CID 74483)

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Source: https://tomesphere.com/paper/PMC12585650