# The Hidden Culprit: Abdominal Tuberculosis Masquerading as Ovarian Cancer in a 22-Year-Old Woman

**Authors:** Sara Adam, Saadia Noreldeen, Amira Hassan, Zaid Aldin, Saimah Arif

PMC · DOI: 10.7759/cureus.95959 · 2025-11-02

## TL;DR

A 22-year-old woman's abdominal tuberculosis was initially mistaken for ovarian cancer, highlighting the difficulty in diagnosing rare conditions.

## Contribution

This case emphasizes the need to consider abdominal TB as a differential diagnosis for adnexal masses and ascites.

## Key findings

- Abdominal TB can mimic ovarian cancer with ascites, adnexal mass, and elevated CA-125 levels.
- Diagnosis requires histopathological and PCR testing, as imaging and tumor markers are insufficient.
- Multispecialty evaluations are often needed due to the complexity of abdominal TB.

## Abstract

Abdominal tuberculosis (TB) is a rare extrapulmonary manifestation of TB in Europe. It may resemble ovarian cancer, especially when ascites, an adnexal mass, and elevated CA-125 levels are present. This case report aims to underline the significance of considering abdominal TB as a differential diagnosis when evaluating ascites with an adnexal mass. The presence of an adnexal mass and ascites should prompt consideration of a TB origin among the possible causes. This case highlights a significant diagnostic challenge, with delays in both diagnosis and management. The patient was evaluated across six specialities (Accident & Emergency, Acute Medicine, Gynaecology, Gynae-Oncology, Infectious Diseases, and Respiratory Medicine), illustrating the complexity and multisystem involvement that contributed to the prolonged diagnostic pathway. Diagnosis of abdominal TB can be challenging and time-consuming. Imaging and tumour markers alone are insufficient. Definitive diagnosis often requires histopathological examination and PCR testing to confirm the presence and nature of the disease.

## Linked entities

- **Diseases:** abdominal tuberculosis (MONDO:0000369), ovarian cancer (MONDO:0005140)

## Full-text entities

- **Genes:** MUC16 (mucin 16, cell surface associated) [NCBI Gene 94025] {aka CA125}
- **Diseases:** ascites (MESH:D001201), tumour (MESH:D009369), Abdominal Tuberculosis (MESH:D000007), adnexal mass (MESH:D000291), Infectious Diseases (MESH:D003141), Ovarian Cancer (MESH:D010051), TB (MESH:D014376)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12585003/full.md

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Source: https://tomesphere.com/paper/PMC12585003