# A case of enterovirus D68-associated acute flaccid myelitis in an immunocompromised adult, Australia

**Authors:** Nathaniel Lizak, Grace Butel-Simoes, Eike Steinig, Belinda Cruse, Edrich Rodrigues, Kirsty Buising, Joe Sasadeusz, Marcelina Krysiak, Bruce Thorley, Matthew Kaye, Leon Caly, Jean Moselen, Ivana Savic, Andrew W. Roberts, Katherine Bond, Chuan Kok Lim, Deborah A. Williamson, Prashanth Ramachandran

PMC · DOI: 10.1128/asmcr.00074-25 · ASM Case Reports · 2025-08-21

## TL;DR

This paper reports a rare case of enterovirus D68 causing acute flaccid myelitis in an immunocompromised adult in Australia.

## Contribution

The study identifies an AFM case in an adult with enterovirus D68, expanding understanding of the disease beyond children.

## Key findings

- Enterovirus D68 was detected in an immunocompromised adult with AFM.
- The virus belongs to the B3 subgroup linked to previous AFM outbreaks.
- This case is phylogenetically connected to AFM cases in the USA and France.

## Abstract

Acute flaccid myelitis (AFM) is a predominantly pediatric, polio-like syndrome associated with enterovirus D68. AFM in adults is rare, reported predominantly in immunocompromised hosts.

Here, we report detection of enterovirus D68 in an immunocompromised Australian adult, specifically the B3 subgroup.

This strain is phylogenetically linked to the 2018 AFM outbreaks in the USA and to documented cases in 2022 in France.

## Linked entities

- **Diseases:** acute flaccid myelitis (MONDO:0100115)

## Full-text entities

- **Diseases:** polio (MESH:D011051), AFM (MESH:C000629404)
- **Species:** enterovirus D68 (no rank) [taxon 42789]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12584186/full.md

## References

17 references — full list in the complete paper: https://tomesphere.com/paper/PMC12584186/full.md

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Source: https://tomesphere.com/paper/PMC12584186