# Synthetic Preparation of the Macrocyclolipopeptide Dysoxylactam A for Potent P‑glycoprotein Inhibition

## TL;DR

This paper describes a new method to synthesize dysoxylactam A, a compound that can help overcome drug resistance in cancer cells.

## Contribution

A reliable and flexible synthetic route for dysoxylactam A is developed using key chemical transformations.

## Key findings

- The synthetic route includes key reactions like Paterson 1,2-anti aldol and Fu–Suzuki coupling.
- The synthesized compound matched the data of the authentic natural product.
- The method is reliable and flexible for producing dysoxylactam A.

## Abstract

In 2019, the cyclolipopeptide dysoxylactam A was isolated
and reported
to be a potent inhibitor of the drug efflux pump P-glycoprotein and
demonstrated the ability to reverse multidrug resistance in cancer
cell lines. Herein, we report a reliable and flexible route toward
dysoxylactam A, which features key transformations such as the Paterson
1,2-anti aldol reaction, an sp3-sp3 Fu–Suzuki coupling, asymmetric allylation, and the
Corey–Nicolaou macrolactonization. All the data obtained on
the synthesized natural product matched those of the authentic material.