# Citrus Flavonoids for Cystic Fibrosis Treatment

## TL;DR

This paper explores how citrus flavonoids could be used to treat cystic fibrosis by targeting multiple aspects of the disease.

## Contribution

The novelty lies in proposing citrus flavonoids as a multitarget treatment for cystic fibrosis.

## Key findings

- Citrus flavonoids show activity as CFTR membrane protein activators.
- They may offer antimicrobial, anti-inflammatory, and immunomodulatory benefits.
- Apt formulations could address multiple disease aspects in cystic fibrosis.

## Abstract

Studies conducted since the late 1990s show substantial activity of selected citrus flavonoids as cystic fibrosis transmembrane conductance regulator (CFTR) membrane protein activators. Aimed at reinvigorating fundamental and applied research on citrus flavonoids for the treatment of mucoviscidosis, the thesis of this work is that aptly formulated citrus flavonoids hold significant potential for developing a multitarget treatment of cystic fibrosis combining in a single treatment antimicrobial, anti‐inflammatory, CFTR‐stimulating, and immunomodulatory properties, as required by a genetic disease eventually causing chronic lung inflammation and bacterial infection reinforcing each other.

Studies conducted since the late 1990s show substantial activity of selected citrus flavonoids as cystic fibrosis transmembrane conductance regulator (CFTR) membrane protein activators. The thesis of this work is that aptly formulated citrus flavonoids hold sigificant potential for developing a multitarget treatment of cystic fibrosis combining in a single treatment antimicrobial, anti‐inflammatory, CFTR‐stimulating, and immunomodulatory properties, as required by a genetic disease eventually causing chronic lung inflammation and bacterial infection reinforcing each other.© 2025 WILEY‐VCH GmbH