# Postoperative opacification of intraocular lens: A case report

**Authors:** Qihang Lei, Xiangli Wang, Qin Liu

PMC · DOI: 10.1016/j.ijscr.2025.112076 · 2025-10-16

## TL;DR

A 76-year-old woman experienced clouding of her artificial eye lens after cataract surgery, which was successfully treated by replacing the lens, highlighting the importance of choosing the right lens material.

## Contribution

The paper emphasizes the importance of hydrophobic acrylic or anti-calcification intraocular lenses to reduce postoperative opacification risks.

## Key findings

- IOL opacification can significantly impair vision and may require surgical intervention.
- Hydrophilic IOLs are more prone to calcification and clouding compared to hydrophobic IOLs.
- Material selection and biological compatibility are critical in preventing postoperative complications.

## Abstract

This case report describes a rare complication of intraocular lens (IOL) opacification in a 76-year-old female patient after age-related cataract surgery in the right eye. Although uncommon, IOL clouding can significantly impair postoperative visual acuity, necessitating surgical intervention. Therefore, choosing the right type of artificial crystal is extremely important.

The patient presented with progressive blurred vision in the right eye for one year. We confirmed the diagnosis and identified the underlying cause after thoroughly excluding other potential influencing factors and make a distinction from congenital cataracts. Subsequently, surgical intervention was performed on the right eye, involving removal of IOL and the re-implantation of new IOL. It resulted in significant improvement in the patient's postoperative vision.

Clouding of the IOL following cataract surgery is characterized by a reduction in lens transparency after implantation. Although relatively uncommon, this complication can significantly impair vision. The etiology of IOL opacification post-surgery primarily encompasses material-related factors, surgical factors, patient-specific factors, and other miscellaneous factors. This case underscores the critical importance of evidence-based IOL selection in cataract surgery to mitigate vision-compromising postoperative complications.

With the advancement of surgical techniques and the introduction of new materials, the incidence of IOL opacification following cataract surgery has significantly decreased. Looking ahead, we will prioritize the use of hydrophobic acrylic IOLs or novel anti-calcification IOLs in future surgeries. This strategic choice aims to further minimize the impact of long-term complications on visual acuity post-cataract surgery.

•The article discusses a 76-year-old woman with worsening vision due to a cloudy intraocular lens after cataract surgery, who successfully had it replaced, improving her quality of life and emphasizing the importance of choosing the appropriate type of artificial lens.•Postoperative opacification of intraocular lenses (IOLs) after cataract surgery can complicate vision recovery, highlighting the need for careful material selection and management, as shown by David J. Apple's lab and Jean Champod's findings.•IOL opacification is a rare complication of cataract surgery, marked by reduced lens transparency and requiring differentiation from other conditions; hydrophilic IOLs are more prone to this issue, while hydrophobic IOLs offer better stability and lower rates, highlighting the importance of careful IOL selection for better visual outcomes.•Hydrophilic intraocular lenses can calcify and become opaque, raising postoperative risks; thus, clinicians should consider biological compatibility and material properties when selecting lenses. Looking ahead, we will prioritize the use of hydrophobic acrylic IOLs or novel anti-calcification IOLs in future surgeries.

The article discusses a 76-year-old woman with worsening vision due to a cloudy intraocular lens after cataract surgery, who successfully had it replaced, improving her quality of life and emphasizing the importance of choosing the appropriate type of artificial lens.

Postoperative opacification of intraocular lenses (IOLs) after cataract surgery can complicate vision recovery, highlighting the need for careful material selection and management, as shown by David J. Apple's lab and Jean Champod's findings.

IOL opacification is a rare complication of cataract surgery, marked by reduced lens transparency and requiring differentiation from other conditions; hydrophilic IOLs are more prone to this issue, while hydrophobic IOLs offer better stability and lower rates, highlighting the importance of careful IOL selection for better visual outcomes.

Hydrophilic intraocular lenses can calcify and become opaque, raising postoperative risks; thus, clinicians should consider biological compatibility and material properties when selecting lenses. Looking ahead, we will prioritize the use of hydrophobic acrylic IOLs or novel anti-calcification IOLs in future surgeries.

## Linked entities

- **Diseases:** cataract (MONDO:0005129)

## Full-text entities

- **Diseases:** lens (MESH:D007905), opacification of (MESH:D058442), blurred vision (MESH:D014786), cataract (MESH:D002386)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12581642/full.md

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Source: https://tomesphere.com/paper/PMC12581642