# Ultrasound-Guided Pulsed Radiofrequency in the Anterior Femoral Cutaneous Nerves to Treat Postherpetic Neuralgia in Anteromedial Thigh: A Case Report

**Authors:** Qing Yuan, Si Chen, Xulei Cui

PMC · DOI: 10.7759/cureus.93821 · 2025-10-04

## TL;DR

A case report shows that pulsed radiofrequency on a specific nerve helped relieve chronic pain from shingles in a patient's thigh.

## Contribution

Demonstrates PRF applied to peripheral nerves as a viable treatment for refractory postherpetic neuralgia.

## Key findings

- PRF applied to the anterior femoral cutaneous nerves provided significant pain relief for PHN in the anteromedial thigh.
- Targeting peripheral nerves with PRF is a safe and effective alternative for treating localized PHN.
- This case suggests a potential expansion of PRF application beyond the dorsal root ganglion for PHN treatment.

## Abstract

Postherpetic neuralgia (PHN) is a typical neuropathic pain after the eruption of the herpes zoster (HZ) rash. Pulsed radiofrequency (PRF) represents a minimally invasive, target-selective neuromodulatory intervention for PHN, with the dorsal root ganglion (DRG) serving as its primary therapeutic target. However, there is a paucity of evidence about the application of PRF to target peripheral nerves to treat PHN, which is easier to access with a lower risk of complications. We describe the successful management of a case by using PRF in the anterior femoral cutaneous nerves (AFCNs) to treat PHN in the anteromedial thigh in a 70-year-old male. This report highlights that PRF directed at peripheral nerves could also yield significant pain relief in chronic localized refractory PHN. Targeting peripheral nerves with PRF emerges as a viable treatment strategy for this patient population.

## Linked entities

- **Diseases:** postherpetic neuralgia (MONDO:0041052), herpes zoster (MONDO:0005609)

## Full-text entities

- **Diseases:** rash (MESH:D005076), pain (MESH:D010146), PHN (MESH:D051474), eruption (MESH:D003875), neuropathic pain (MESH:D009437), HZ (MESH:D006562)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12581150/full.md

---
Source: https://tomesphere.com/paper/PMC12581150