# Comparative analysis of complanadine A total syntheses

## TL;DR

This paper reviews four different ways to synthesize complanadine A, a complex natural compound with potential for treating pain and promoting nerve growth.

## Contribution

The paper provides a comparative analysis of four innovative total syntheses of complanadine A from different research groups.

## Key findings

- Four distinct total syntheses of complanadine A are reviewed, each showcasing unique strategies.
- The syntheses highlight the impact of emerging synthetic methods on natural product synthesis.
- The review emphasizes complanadine A's potential in neurotrophic activity and pain management.

## Abstract

In this review, we summarize and compare four total syntheses of complanadine A, a complex and pseudo-dimeric lycopodium alkaloid with promising neurotrophic activity and potential for pain management. These four total syntheses are from the groups of Siegel, Sarpong, Tsukano, and Dai. Each of the four total syntheses contains innovative strategies and creative tactics, reflecting how emerging synthetic capabilities and concepts can positively impact natural product total synthesis.