# Pathway economy in cyclization of 1,n-enynes

## TL;DR

This paper introduces a new strategy for efficiently creating complex molecules from a single starting material using controlled chemical reactions.

## Contribution

The novel 'pathway economy' strategy enables precise control over cyclization reactions using catalysts and other parameters.

## Key findings

- The pathway economy strategy allows for divergent synthesis from a single substrate class.
- The approach offers superior temporal and step efficiency compared to traditional methods.
- It provides a sustainable framework for molecular diversification with applications in green chemistry.

## Abstract

This review presents a paradigm-shifting "pathway economy" strategy for 1,n-enyne cyclization, enabling divergent construction of complex molecular architectures from a single substrate class. Through mechanistic-guided modulation of catalysts, solvents, ligands, and angle strain, this approach achieves unprecedented reaction pathway control while demonstrating superior temporal and step efficiency compared to conventional methods. The work establishes a sustainable framework for rapid molecular diversification, offering transformative potential for green chemistry and pharmaceutical applications. By unifying mechanistic insights with practical synthetic design, this review provides valuable guidance for future innovations in precision organic synthesis.