Recurrent fever, persistent cytopenia
祎 缪, 菁 张, 涵 张, 重阳 丁, 震 王, 忠兰 苏, 建勇 李, 文瑜 施
TL;DR
This paper presents a case of a rare type of lymphoma with recurring fever and blood cell reduction, highlighting the challenges in diagnosis and treatment.
Contribution
The paper provides a clinical case study of IVLBCL with multidisciplinary insights to improve future diagnosis and treatment strategies.
Findings
The patient was diagnosed with IVLBCL after multiple tests and biopsies.
Despite R-CHOP treatment, the disease progressed rapidly, leading to the patient's death.
The case emphasizes the importance of multidisciplinary collaboration in managing IVLBCL.
Abstract
血管内大B细胞淋巴瘤（IVLBCL）是一种罕见类型的大B细胞淋巴瘤。本文报道了一例因“反复发热、全血细胞减少”就诊的病例。患者，女，64岁，既往诊断华氏巨球蛋白血症，曾接受泽布替尼治疗。2023年2月因“反复发热、全血细胞减少”就诊，PET-CT示双侧肾上腺明显肿大，经肾上腺穿刺活检诊断为弥漫大B细胞淋巴瘤，非特指型。患者接受R-CHOP（利妥昔单抗+环磷酰胺+多柔比星+长春新碱+泼尼松）方案化疗，3个疗程后经头颅MRI检查提示淋巴瘤中枢神经系统浸润。回顾病理检查，最终诊断为IVLBCL。尽管积极治疗，但患者疾病持续进展，于2个月后死亡。本文基于多学科层面，结合该病例，从多学科团队协作角度展开论述，旨在为IVLBCL的临床诊疗提供参考意见。
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Taxonomy
TopicsCNS Lymphoma Diagnosis and Treatment · Chronic Lymphocytic Leukemia Research · Autoimmune Neurological Disorders and Treatments