# Multiple inositol polyphosphate phosphatase: a hidden phytate digester with bioactive function potential in animal husbandry: review

## TL;DR

This review explores the unique properties and potential uses of MINPP1, an unusual enzyme that breaks down phytate and may improve animal health and feed efficiency.

## Contribution

The paper highlights MINPP1's distinct enzymatic features and its potential physiological roles in animals, suggesting new applications in animal husbandry.

## Key findings

- MINPP1 has unique enzymatic properties suitable for phytate degradation in animal feed.
- MINPP1 is involved in biological processes like inflammation and metabolism, which could impact animal production.
- Further research is needed to confirm MINPP1's direct effects on animal physiology.

## Abstract

The objective of this review was to describe the enzymatic properties of multiple inositol polyphosphate phosphatase (MINPP1/MIPP) as an unusual member of histidine acid phosphatase, distinct from conventional microbial phytases and their additional physiological functions besides degrading phytate. Considering parameters such as pH activity profile, substrate specificity, catalytic efficiency, and stability, MINPP1 is of merit as a novel phytase source for developing an ideal feed additive supported by functional metagenomics fused with recombinant DNA technology and classical protein engineering. In addition, MINPP1 appears to be involved in some biological activities such as cell survival, stress, lipopolysaccharide and inorganic polyphosphate-induced inflammatory response, milk fatty acid composition-related metabolism and bone-related growth and pathophysiology, which can be important for the production performance of farm animals. Future directions need profound studies revealing the direct effects of MINPP1 on these physiological events.