# Deceptive appearance of primary mucinous carcinoma of the eyelid: A rare case and literature review

**Authors:** Sonali Vinay Kumar, Manoj Gopal Madakshira, Vinay Kumar, Sanjay Kumar Mishra, Alok Sati, Natasha Vinay Kumar

PMC · DOI: 10.22336/rjo.2025.48 · 2025-07-01

## TL;DR

A rare eyelid cancer mimicked a benign growth, leading to a delayed diagnosis and highlighting the need for careful evaluation.

## Contribution

The paper presents a rare case of primary mucinous carcinoma of the eyelid with a deceptive clinical appearance.

## Key findings

- PMC was misdiagnosed as benign due to its slow-growing and innocuous appearance.
- Histopathological evaluation was crucial for accurate diagnosis.
- The patient remained recurrence-free for two years without surgery.

## Abstract

Primary mucinous carcinoma (PMC) of the eyelid is an exceedingly rare malignancy that often presents as an innocuous, slow-growing lesion, leading to frequent misdiagnosis as a benign entity. This diagnostic challenge can lead to delayed treatment and potential recurrence. We report a unique case of PMC in a patient who presented with a clinically benign-appearing lesion, initially considered for differential diagnoses such as keratoacanthoma, epidermoid cyst, and pilomatrixoma. A diagnostic surprise emerged when histopathological evaluation confirmed PMC. Despite recommendations for wide local excision, the patient opted for observation due to concerns about postoperative morbidity. Over a two-year follow-up period, no recurrence was noted. This case highlights the deceptive presentation of PMC, the importance of histopathological confirmation, and the role of individualized patient management. A review of the literature further underscores the rarity of this entity and the necessity for long-term surveillance.

## Linked entities

- **Diseases:** keratoacanthoma (MONDO:0002527), epidermoid cyst (MONDO:0007547), pilomatrixoma (MONDO:0007564)

## Full-text entities

- **Diseases:** keratoacanthoma (MESH:D007636), PMC (MESH:D002288), malignancy (MESH:D009369), mucinous carcinoma of the eyelid (MESH:D005142), pilomatrixoma (MESH:D018296), epidermoid cyst (MESH:D004814)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12580670/full.md

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Source: https://tomesphere.com/paper/PMC12580670