OCT-Based Analysis of Post-Lens Tear Film Stability in Silicone Hydrogel Contact Lenses

TL;DR

This study uses OCT to show that wearing silicone hydrogel contact lenses for weeks reduces tear film stability and thickness, which could lead to discomfort and eye issues.

Contribution

The study introduces OCT-based monitoring of post-lens tear film stability in silicone hydrogel contact lenses.

Findings

PLTF stability decreased significantly after 2-4 weeks of contact lens wear.

PoLTF thickness in the central cornea reduced significantly after prolonged lens use.

Monitoring tear film parameters with OCT can help prevent contact lens intolerance.

Abstract

This study aimed to evaluate the stability of post-lens tear film (PoLTF) and pre-lens tear film (PLTF) in three different silicone hydrogel contact lenses (CLs) using optical coherence tomography (OCT) and multifunctional topography.

A total of 158 participants were assigned to three groups based on the CL material: Group 1 (Lotrafilcon B), Group 2 (Senofilcon A), and Group 3 (Samfilcon A). Non-invasive average break-up time (NIAvgBUT) of the PLTF was measured after a few hours of lens wear during the first visit and after 2-4 weeks of continued use in the second visit. PoLTF thickness was assessed in five corneal quadrants using OCT, measured both indirectly and manually.

The mean participant age was 21.9±5.0 years. The NIAvgBUT of the PLTF was significantly higher at the first visit than at the second visit (9.5±2.9 s vs. 8.3±2.1 s, p=0.0001). Similarly, the PoLTF thickness in the central corneal area showed a significant reduction after 2-4 weeks of lens wear (p=0.001).

Our results emphasize the clinical importance of monitoring both pre-lens and post-lens tear film parameters during routine follow-up visits. By integrating OCT-based measurements into daily practice, clinicians may identify early tear film instability and prevent contact lens intolerance. This is particularly relevant for younger patients who are at risk of long-term ocular surface changes due to extended lens wear.

A significant decrease in PLTF stability (NIAvgBUT) and PoLTF thickness in the central corneal area was observed after 2-4 weeks of CL use. These findings suggest that prolonged CL wear affects tear film stability and surface wettability, highlighting the importance of monitoring these changes over time.

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