# Associations between attenuated auditory p300 event‐related potential and cognitive basic symptoms in young people at clinical high risk for psychosis

## TL;DR

This study finds that cognitive symptoms in people at risk for psychosis are linked to reduced brain activity in a specific brain region.

## Contribution

The study identifies a novel association between cognitive basic symptoms and attenuated P3b amplitude in the right temporo-parietal area in clinical high-risk individuals.

## Key findings

- COGDIS scores were associated with reduced P3b amplitude at the P4 electrode.
- This effect was independent of positive or negative symptom severity.
- No differences in brain connectivity strength or modulation were observed.

## Abstract

The value of assessing basic symptoms in clinical‐high‐risk for psychosis (CHR) is becoming increasingly apparent. Greater recognition of subjective experience in neuroscience and psychiatry has renewed research interest in electrophysiological biomarkers of basic symptoms. This study aims to investigate whether cognitive basic symptoms (COGDIS), which capture a subset of basic symptoms, are associated with P3b attenuation and the modulation of brain connectivity in a large sample of CHR.

Data from the North American Prodromal Longitudinal Study‐ 3 (NAPLS‐3) comprised 440 male and female CHR individuals who completed both the COGDIS items of the schizophrenia proneness instrument as well as a two‐tone auditory oddball task. P3b amplitude was measured at the central (Cz) as well as left (P3) and right (P4) parietal electrodes. Brain connectivity was calculated across 300 ms windows before (−300 ms to 0 ms) and after (100 ms to 400 ms) onset of target stimuli. Brain connectivity modulation was calculated as the difference between pre‐stimulus and post‐stimulus windows.

Multiple linear regression analysis indicated that COGDIS was associated with reduced P3b amplitude at the P4 electrode. This effect was not associated with the severity of positive or negative symptoms. No differences in connectivity strength or modulation were found between the groups.

In a large sample of CHR/UHR individuals, cognitive basic symptoms criteria was associated with reduced P3b amplitude at the P4 electrode, approximating the right temporo‐parietal area. Parietal P3b attenuation may reflect greater preoccupation towards sensory data, which could play a role in cognitive basic symptom pathogenesis.