# Translational insights into pain mechanisms and balance impairments in aging: a cross-sectional study

**Authors:** Mastour Saeed Alshahrani, Ravi Shankar Reddy

PMC · DOI: 10.3389/fnagi.2025.1656854 · Frontiers in Aging Neuroscience · 2025-10-20

## TL;DR

This study finds that pain sensitivity and chronic pain are linked to worse balance in older adults, suggesting the need for comprehensive pain assessments in balance evaluations.

## Contribution

The study demonstrates that both sensory and cognitive-affective pain dimensions independently affect postural stability in aging.

## Key findings

- Sway velocity is significantly predicted by pain threshold, pain intensity, and catastrophizing.
- Chronic pain is associated with reduced functional reach performance.
- Longer pain duration correlates with increased sway area in older adults.

## Abstract

This study aimed to investigate the association between pressure pain threshold (PPT), pain intensity, pain catastrophizing, and postural stability and to assess the impact of pain chronicity and duration on functional reach and posturographic outcomes in community-dwelling older adults.

A cross-sectional study was conducted involving 136 older adults (mean age = 74.23 ± 6.52 years). Pain mechanisms were assessed using an algometer (PPT), the Numeric Pain Rating Scale (NPRS), and the Pain Catastrophizing Scale (PCS). Balance was evaluated via force plate posturography (sway metrics) and the Functional Reach Test (FRT). Covariates included Mini-Cog and Geriatric Depression Scale scores. Data were analyzed using Pearson correlations, multiple linear regression, and ANCOVA.

Sway velocity was significantly predicted by PPT (B = 0.47, p < 0.001), NPRS (B = −0.36, p < 0.001), PCS (B = −0.29, p = 0.001), Mini-Cog (B = 0.33, p = 0.003), and GDS (B = −0.18, p = 0.011), explaining 48% of the variance (R2 = 0.48, F(5,130) = 24.15, p < 0.001). Chronic pain was associated with reduced FRT performance (F = 9.45, p = 0.003), and longer pain duration predicted greater sway area (B = 0.014 ± 0.004, p = 0.001).

Both sensory and cognitive-affective dimensions of pain, along with pain chronicity, are independently associated with postural stability impairments in older adults. These findings support the integration of multidimensional pain assessments in clinical balance evaluations.

## Full-text entities

- **Diseases:** balance impairments (MESH:D060825), postural stability impairments (MESH:D043171), Chronic pain (MESH:D059350), Pain (MESH:D010146), Depression (MESH:D003866)

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12580282/full.md

## References

37 references — full list in the complete paper: https://tomesphere.com/paper/PMC12580282/full.md

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Source: https://tomesphere.com/paper/PMC12580282