# Editorial: Advances and applications of predictive toxicology in knowledge discovery, risk assessment, and drug development

**Authors:** Fengxian Zhang, Feiyu Li, Jiaqi Tan, Nan Zhang, Yonglong Han, Jiayu Liao, Huaqiang Zhai

PMC · DOI: 10.3389/fphar.2025.1721364 · Frontiers in Pharmacology · 2025-10-20

## Full-text entities

- **Genes:** KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845] {aka 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A}, THBS1 (thrombospondin 1) [NCBI Gene 487486], HLA-A (major histocompatibility complex, class I, A) [NCBI Gene 3105] {aka HLAA}, PPARA (peroxisome proliferator activated receptor alpha) [NCBI Gene 403654]
- **Diseases:** hepatobiliary disorders (MESH:D004066), osteoporosis (MESH:D010024), toxicities (MESH:D064420), bone loss (MESH:D001847), Gastrointestinal and endocrine disorders (MESH:D005767), thrombocytopenia (MESH:D013921), neurotoxicity (MESH:D020258), gastrointestinal bleeding (MESH:D006471), overdose (MESH:D062787), skin and appendage damage (MESH:D018280), acute and chronic toxicity (MESH:D000208), cardiotoxicity (MESH:D066126), allergic reactions (MESH:D004342), liver toxicity (MESH:D056486), renal injuries (MESH:D007674)
- **Chemicals:** linezolid (MESH:D000069349), omeprazole (MESH:D009853), fenofibrate (MESH:D011345), entrectinib (MESH:C000607349), doxorubicin (MESH:D004317), anthracyclines (MESH:D018943), bile acid (MESH:D001647), Aconitum alkaloids (-), sotorasib (MESH:C000706028), levothyroxine (MESH:D013974), rosuvastatin (MESH:D000068718), dopamine (MESH:D004298), lipid (MESH:D008055), adagrasib (MESH:C000718190)
- **Species:** Homo sapiens (human, species) [taxon 9606], Canis lupus familiaris (dog, subspecies) [taxon 9615], Rattus norvegicus (brown rat, species) [taxon 10116], Danio rerio (leopard danio, species) [taxon 7955]
- **Mutations:** G12C
- **Cell lines:** HepG2 — Homo sapiens (Human), Hepatoblastoma, Cancer cell line (CVCL_0027)

## Full text

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## References

2 references — full list in the complete paper: https://tomesphere.com/paper/PMC12580204/full.md

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Source: https://tomesphere.com/paper/PMC12580204