# Identifying the correlation between the number of OGTT abnormalities and perinatal outcomes in twin pregnancies: a retrospective cohort study

## TL;DR

This study explores how the number of abnormal glucose test results in twin pregnancies relates to risks of complications like gestational hypertension and cholestasis.

## Contribution

The study identifies a correlation between the number of abnormal OGTT values and specific adverse perinatal outcomes in twin pregnancies.

## Key findings

- More abnormal OGTT values are linked to higher risks of gestational hypertension and intrahepatic cholestasis in twin pregnancies.
- Logistic regression confirmed associations between abnormal glucose levels and adverse outcomes in assisted reproduction twin pregnancies.

## Abstract

Gestational diabetes mellitus (GDM) is a common metabolic disorder during pregnancy and is particularly significant in twin pregnancies due to their inherently higher risk of adverse perinatal outcomes. Identifying the correlation between the degree of glucose intolerance and perinatal outcomes can provide valuable insights for clinical management. This study aimed to investigate the risk of developing adverse perinatal outcomes in pregnant women and fetuses with twin births by the number of abnormal values of oral 75 g glucose tolerance test (OGTT).

We conducted a population-based retrospective cohort study in which 3545 pregnant women with twin pregnancies in Women’s and Children’s Hospital of Chongqing Medical University underwent an oral 75 g glucose tolerance test to collect fasting, 1-hour postprandial, and 2-hour postprandial glucose, and to collect the perinatal outcomes of pregnant women and fetuses in the set.

Logistic regression analysis showed that the number of abnormal OGTTs was associated with the risk of expected adverse perinatal outcomes. In the unadjusted model, the prevalence of gestational hypertension, intrahepatic cholestasis in pregnancy, and hypoproteinemia in pregnancy were statistically significant. In the adjusted model, the prevalence of gestational hypertension and intrahepatic cholestasis in pregnancy was statistically significant.

The number of abnormal OGTTs was associated with the incidence of gestational hypertension and intrahepatic cholestasis in pregnancy in twin pregnancies that had undergone assisted reproduction. These findings highlight the importance of closely monitoring glucose levels in such pregnancies to mitigate associated risks.