# A Case of Large Cell Neuroendocrine Carcinoma of the Bladder With Long‐Term Control by Metastasectomy

## TL;DR

A rare bladder cancer case was successfully managed with surgery to remove the primary tumor and two distant metastases, resulting in long-term remission.

## Contribution

This case report demonstrates the potential effectiveness of metastasectomy for solitary metastases in LCNEC of the bladder.

## Key findings

- The patient remained disease-free for 42 months after the second metastasectomy.
- Surgical removal of solitary metastases may offer long-term control in LCNEC of the bladder.
- No additional treatment was needed after metastasectomy, with no recurrence observed.

## Abstract

Large cell neuroendocrine carcinoma (LCNEC) of the bladder is rare and aggressive. Reports of metastasectomy for single distant metastases are even rarer.

A 49‐year‐old man was admitted to our hospital with gross hematuria. Cystoscopy, magnetic resonance imaging, and computed tomography revealed invasive bladder cancer without metastasis. He underwent transurethral resection of the bladder tumor, and histopathological examination confirmed LCNEC. The patient received neoadjuvant chemotherapy followed by partial cystectomy. Nineteen months postoperatively, a solitary metastasis was detected in the right axillary lymph node, and at 44 months, another solitary metastasis appeared in the subcutaneous tissue outside the right scapula. Both metastases were surgically resected, and no additional treatment was administered. At the time of this writing, there had been no recurrence or metastasis for 42 months following the second metastasectomy.

Metastasectomy may be an effective treatment option for solitary metastasis of LCNEC of the bladder.