# A Case of Spermatocytic Tumor of Testis

**Authors:** Satsuki Nagamine, Yosuke Nakanishi, Kei Tanaka, Asuka Ashikari, Ryu Kimura, Shotaro Nakanishi, Rin Kawamitsu, Naoki Wada, Akihiro Nishie, Junichi Inokuchi

PMC · DOI: 10.1002/iju5.70089 · IJU Case Reports · 2025-10-22

## TL;DR

A rare testicular tumor called spermatocytic tumor was diagnosed in a 51-year-old man through surgery and lab tests, with a generally good outlook after treatment.

## Contribution

This paper presents a clinical case of a rare spermatocytic tumor of the testis with detailed diagnostic findings.

## Key findings

- The tumor was diagnosed as spermatocytic based on histopathological and immunohistochemical features.
- The patient had normal tumor markers and no sarcomatoid or anaplastic features in the tumor.
- The case highlights the importance of long-term follow-up due to potential late metastasis.

## Abstract

Spermatocytic tumor is a rare type of testicular germ cell tumor, accounting for approximately 1% of all testicular neoplasms.

A 51‐year‐old male presented to the hospital with a painless mass in the left testis. Ultrasonography revealed a heterogeneous intratesticular mass with cystic components. Testicular tumor markers were within normal ranges. The patient underwent a left orchiectomy. Pathologically, the tumor was characterized by the presence of medium to large neoplastic cells and small neoplastic cells without sarcomatoid or anaplastic features. Immunohistochemically, the tumor was positive for SALL4 and negative for CD30, AFP, OCT3/4, PLAP, D2‐40, and hCG. Based on these findings, we diagnosed spermatocytic tumor of testis.

We present a case of spermatocytic tumor, which is a distinct entity among testicular germ cell tumors, with a generally favorable prognosis following orchiectomy. However, long‐term follow‐up is recommended due to the potential for late metastasis.

## Linked entities

- **Proteins:** SALL4 (spalt like transcription factor 4), TNFRSF8 (TNF receptor superfamily member 8), AFP (alpha fetoprotein), POU5F1 (POU class 5 homeobox 1), ALPP (alkaline phosphatase, placental), PDPN (podoplanin), CGA (glycoprotein hormones, alpha polypeptide)

## Full-text entities

- **Genes:** TNFRSF8 (TNF receptor superfamily member 8) [NCBI Gene 943] {aka CD30, D1S166E, Ki-1}, PLAA (phospholipase A2 activating protein) [NCBI Gene 9373] {aka DOA1, NDMSBA, PLA2P, PLAP}, HTC2 (hypertrichosis 2 (generalized, congenital)) [NCBI Gene 3342] {aka CGH, CXINSq27.1, HCG}, AFP (alpha fetoprotein) [NCBI Gene 174] {aka AFPD, FETA, HPAFP}, SALL4 (spalt like transcription factor 4) [NCBI Gene 57167] {aka DRRS, HSAL4, IVIC, ZNF797}
- **Diseases:** metastasis (MESH:D009362), tumor (MESH:D009369), Spermatocytic tumor (MESH:C563236), Spermatocytic Tumor of Testis (MESH:D013736)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12580010/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12580010/full.md

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Source: https://tomesphere.com/paper/PMC12580010