# Effect of Continuous Renal Replacement Therapy Using oXiris Hemofilter in a Critically Ill Patient With Sepsis and Acute Respiratory Distress Syndrome

## TL;DR

This case report shows that using the oXiris hemofilter during CRRT can safely help a critically ill sepsis patient with ARDS and kidney failure.

## Contribution

Demonstrates the feasibility and safety of using oXiris hemofilter in septic patients with acute kidney injury and cytokine storm.

## Key findings

- The patient showed clinical improvement without adverse effects using the oXiris filter.
- CRRT with oXiris may be an effective adjunctive treatment for sepsis-induced acute kidney injury and cytokine storm.
- The treatment approach was well-tolerated in a patient with multiple comorbidities.

## Abstract

Acute respiratory distress syndrome (ARDS) and sepsis represent severe and often life-threatening conditions, especially in critically ill patients with multiple comorbidities. This case report details the management of a 59-year-old male patient with a complicated medical history, including ischemic heart disease (IHD), hypertension (HTN), diabetes mellitus (DM), and chronic kidney disease (CKD). The patient was admitted to the intensive care unit (ICU) due to acutely decompensated heart failure (HF) and subsequent sepsis, leading to ARDS. His treatment involved initiating continuous renal replacement therapy (CRRT) using the oXiris filter (Baxter International Inc., Deerfield, IL, USA), known for its ability to adsorb cytokines. The oXiris filter was employed as part of a multifaceted approach to manage the patient's acute kidney injury (AKI) in the context of septic shock and a cytokine storm. Remarkably, no adverse effects were noted, and the patient demonstrated clinical improvement. This case supports the feasibility and safety of using CRRT with the oXiris filter in septic patients with AKI and a cytokine storm, providing an effective adjunctive treatment strategy. This technique may offer potential benefits in managing critically ill patients with complex comorbid conditions, highlighting its possible role in improving outcomes for similar clinical scenarios.