# Recurrent Reactive Infectious Mucocutaneous Eruption (RIME) in a Pediatric Patient Triggered by Mycoplasma pneumoniae and Enterovirus Coinfection

**Authors:** Mohamad B Alebaji, Anna Tryfonos, Bhavya Vasantham, Ratna Basak

PMC · DOI: 10.7759/cureus.93698 · Cureus · 2025-10-02

## TL;DR

A 10-year-old boy developed a rare skin and mucous membrane condition caused by a co-infection of two viruses, which was initially mistaken for a more severe disease.

## Contribution

This case highlights a rare co-infection and unusual urethral manifestation associated with RIME in a pediatric patient.

## Key findings

- The patient exhibited fever, cough, oral ulcers, and conjunctival injection.
- The condition involved severe mucositis with urethral involvement.
- The eruption was linked to a co-infection by Mycoplasma pneumoniae and enterovirus.

## Abstract

Reactive infectious mucocutaneous eruption (RIME) is an underrecognized condition often misdiagnosed as Stevens-Johnson syndrome (SJS). We present a case of a 10-year-old boy who presented with fever, cough, painful oral ulcers, and conjunctival injection that progressed to severe mucositis with urethral involvement. This case is notable both for the unusual urethral manifestation and for its association with a rare co-infection by Mycoplasma pneumoniae and enterovirus, attributable to RIME.

## Linked entities

- **Diseases:** Stevens-Johnson syndrome (MONDO:0018229)

## Full-text entities

- **Diseases:** oral ulcers (MESH:D019226), mucositis (MESH:D052016), Enterovirus Coinfection (MESH:D060085), SJS (MESH:D013262), fever (MESH:D005334), cough (MESH:D003371), RIME (MESH:D000085343), infection (MESH:D007239)
- **Species:** Mycoplasmoides pneumoniae (Filterable agent of primary atypical pneumonia, species) [taxon 2104], Enterovirus (genus) [taxon 12059], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12579381/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12579381/full.md

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Source: https://tomesphere.com/paper/PMC12579381