# Angiogenesis and lymphangiogenesis in primary cutaneous lymphomas: a narrative review

## TL;DR

This paper reviews how blood and lymph vessel formation relates to the development and progression of skin lymphomas, focusing on T and B cell types.

## Contribution

The paper provides a comprehensive review of angiogenesis and lymphangiogenesis in primary cutaneous lymphomas, emphasizing molecular mechanisms.

## Key findings

- Angiogenesis correlates with tumor aggressiveness in primary cutaneous lymphomas.
- Most data on angiogenesis in these lymphomas come from T cell lymphomas like mycosis fungoides.
- The role of lymphangiogenesis in B cell lymphomas remains less understood.

## Abstract

Angiogenesis and lymphangiogenesis are hallmarks of cancer and widely investigated both in solid and hematologic malignancies, correlating with tumor aggressiveness and progression. To date, the meaning of angiogenesis in primary cutaneous lymphomas has not been fully clarified, with most data coming from T cell lymphomas, in particular mycosis fungoides. Herein, we provide a comprehensive review about their significance in both primary cutaneous T cell and B cell lymphomas, with the aim to deepen the underlying molecular mechanism and role in tumor development and progression.