# Parathyromatosis: A Challenging Management in a Young Girl Case Report With Literature Review

**Authors:** Grace Jrad, Rim Masri, Bassam Abboud, Claude Ghorra, Charbel Mourad

PMC · DOI: 10.1155/crie/9239048 · Case Reports in Endocrinology · 2025-10-24

## TL;DR

This paper presents a rare case of parathyromatosis in a young girl, highlighting the challenges in diagnosing and managing this condition.

## Contribution

The case is the youngest reported instance of parathyromatosis, emphasizing its management difficulties.

## Key findings

- Parathyromatosis can occur after parathyroidectomy in young patients.
- Multiple imaging modalities are needed for accurate diagnosis and localization.
- The condition can lead to severe renal and bone complications.

## Abstract

Parathytomatosis is a rare cause of persistent or recurrent hyperparathyroidism, defined by the presence of hyperfunctioning parathyroid tissues scattered throughout the neck and mediastinum. Preoperative diagnosis and localization of all the seeded parathyroid tissue is difficult, therefore, many imaging modalities are needed to determine the localization of these lesions for a more successful outcome. We report a case of a young girl with a severe primary hyperparathyroidism (PHPT) from a parathyroid adenoma, with renal and bone complications. She underwent parathyroidectomy and developed 2 years later recurrent disease in the form of parathyromatosis. We review the different tools for diagnosis and management since this condition remains a challenging issue. To our best knowledge, this case is the youngest case described in the literature and highlights the difficulties of management of parathyromatosis and the potential complications that may ensue from this disease.

## Linked entities

- **Diseases:** primary hyperparathyroidism (MONDO:0010837)

## Full-text entities

- **Diseases:** PHPT (MESH:D049950), parathyroid adenoma (MESH:D010282), hyperparathyroidism (MESH:D006961)

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12578562/full.md

## References

25 references — full list in the complete paper: https://tomesphere.com/paper/PMC12578562/full.md

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Source: https://tomesphere.com/paper/PMC12578562