# Cerebrolysin treatment in a case of post-herpes simplex encephalitis with neuropsychiatric symptoms

**Authors:** Young Seok Lee, Jinmi Seo, Soo Hwan Yim

PMC · DOI: 10.25122/jml-2025-0052 · Journal of Medicine and Life · 2025-09-01

## TL;DR

A patient with brain inflammation from herpes showed improved mental symptoms after treatment with Cerebrolysin.

## Contribution

Demonstrates potential of Cerebrolysin in treating post-encephalitic neuropsychiatric symptoms.

## Key findings

- A 33-year-old patient showed significant improvement after Cerebrolysin treatment.
- Cerebrolysin may help manage cognitive dysfunction following herpes encephalitis.
- Standard antiviral and steroid treatments were followed by Cerebrolysin with positive results.

## Abstract

Herpes simplex encephalitis (HSE) is a severe central nervous system (CNS) infection associated with cognitive decline, psychotic symptoms, and epilepsy. Despite aggressive antiviral and corticosteroid treatments, post-HSE complications remain challenging to manage. We report a case of a 33-year-old female patient with post-HSE neuropsychiatric symptoms who showed significant improvement following Cerebrolysin treatment. The patient was treated with acyclovir and dexamethasone in the acute phase, followed by Cerebrolysin administration in the post-acute phase. This case highlights the potential therapeutic role of Cerebrolysin in managing post-encephalitic cognitive dysfunction, underscoring the need for further studies.

## Linked entities

- **Chemicals:** acyclovir (PubChem CID 135398513), dexamethasone (PubChem CID 5743)
- **Diseases:** herpes simplex encephalitis (MONDO:0012521), epilepsy (MONDO:0005027)

## Full-text entities

- **Diseases:** cognitive decline (MESH:D003072), central nervous system (CNS) infection (MESH:D002494), epilepsy (MESH:D004827), encephalitic (MESH:D010301), neuropsychiatric symptoms (MESH:D001523), HSE (MESH:D020803), psychotic symptoms (MESH:D011618), post (MESH:D000094025)
- **Chemicals:** acyclovir (MESH:D000212), Cerebrolysin (MESH:C006952), dexamethasone (MESH:D003907)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12577782/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12577782/full.md

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Source: https://tomesphere.com/paper/PMC12577782