# Skel-Net: automatic prediction of skeletal pattern on scanned lateral cephalograms using anatomical prior-guided deep learning network

## TL;DR

Skel-Net is a deep learning model that predicts craniofacial growth patterns from cephalograms, improving orthodontic treatment planning.

## Contribution

Skel-Net introduces an anatomic prior-guided deep learning framework for dynamic craniofacial growth prediction.

## Key findings

- Skel-Net achieved a mean absolute error of 1.021 degrees in predicting ANB angle changes.
- The model outperformed other architectures like DenseNet121 and ResNet101 in prediction accuracy.

## Abstract

Estimating craniofacial patterns is essential for successful orthodontic treatment. However, conventional static measurements are inadequate for capturing dynamic changes, and manual cephalometric analysis is labor-intensive and requires specialized expertise. In this study, we propose Skel-Net, a novel anatomic prior-guided deep learning network designed to estimate ANB angle changes over five years in children and adolescents aged 8–16.

In a two-stage approach, Skel-Net combines cephalometric landmark detection via Ceph-Net and multichannel inputs, including two-dimensional heatmaps and ANB priors, to enhance prediction accuracy. A dataset of 612 lateral cephalograms from 245 patients was used to train and validate the model, and its performance was compared against DenseNet121, MobileNetV2, ResNet101, and VGG16.

Skel-Net outperformed the other models with the lowest prediction errors (mean absolute error: 1.021 degrees; root mean squared error: 1.338 degrees) and the highest R2 value (0.517), demonstrating robust predictive capabilities.

By leveraging anatomic priors and longitudinal data, Skel-Net enables dynamic and personalized predictions of craniofacial growth. This framework will facilitate early and precise orthodontic interventions, enhancing treatment efficiency, stability, and overall patient outcomes.