# Pancreatic Intraductal Papillary Mucinous Neoplasm With Invasive Carcinoma Concomitant With Ampullary Neuroendocrine Tumor: A Case Report

**Authors:** Jingcheng Zhang, Jianhao Huang, Xiaodong He, Mengqing Sun, Xianlin Han

PMC · DOI: 10.1002/ccr3.71309 · 2025-10-31

## TL;DR

This case report describes a rare situation where two tumors occurred together in a patient's pancreas and ampulla, requiring surgery and close monitoring.

## Contribution

The novelty lies in documenting a rare co-occurrence of pancreatic and ampullary tumors with lymph node metastasis.

## Key findings

- A patient had pancreatic intraductal papillary mucinous neoplasm with invasive carcinoma and ampullary neuroendocrine tumor.
- Laparoscopic pancreaticoduodenectomy was performed with no recurrence in 12 months.
- Both tumors showed lymph node metastasis, highlighting the need for timely biopsy.

## Abstract

This case reports a rare co‐occurrence of pancreatic intraductal papillary mucinous neoplasm with invasive carcinoma and ampullary neuroendocrine tumor. Laparoscopic pancreaticoduodenectomy was done. No recurrence/metastasis in 12‐month follow‐up, though both tumors had lymph node metastasis, warranting attention to timely biopsy.

## Linked entities

- **Diseases:** pancreatic intraductal papillary mucinous neoplasm (MONDO:0004286), invasive carcinoma (MONDO:0040677)

## Full-text entities

- **Diseases:** metastasis (MESH:D009362), tumors (MESH:D009369), lymph node metastasis (MESH:D008207), Ampullary Neuroendocrine Tumor (MESH:D018358), Pancreatic Intraductal Papillary Mucinous Neoplasm (MESH:D000077779), Invasive Carcinoma (MESH:D009361)

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12576143/full.md

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Source: https://tomesphere.com/paper/PMC12576143