# The Clinical Spectrum of Hypophosphatasia in Older Adults

## TL;DR

This paper discusses the importance of diagnosing hypophosphatasia in older adults to avoid inappropriate osteoporosis treatments.

## Contribution

It emphasizes measuring alkaline phosphatase in older adults with fragility fractures to identify hypophosphatasia.

## Key findings

- Low serum alkaline phosphatase levels may indicate hypophosphatasia in older adults with fragility fractures.
- Correct diagnosis of HPP prevents the use of contraindicated antiresorptive medications.

## Abstract

Alkaline phosphatase (ALP) should be measured in older adults presenting with fragility fractures. Hypophosphatasia (HPP) should be suspected in individuals with hypophosphatasemia (low serum ALP). A correct diagnosis allows clinicians to avoid using potent antiresorptive osteoporosis medications, which are contraindicated in patients with HPP.