# IgG‐Secreting Lymphoplasmacytic Lymphoma Presenting With Massive Kidney Infiltration

**Authors:** Yuichi Nakamura, Yoshihiro Itoh, Tomoyuki Sakamoto, Emi Kakegawa, Yasuhito Terui, Taichi Tarusawa, Tsutomu Inoue, Hirokazu Okada, Keisuke Ishizawa, Taketo Yamada

PMC · DOI: 10.1002/ccr3.71290 · 2025-10-30

## TL;DR

A rare case of IgG-secreting lymphoplasmacytic lymphoma caused kidney damage, which improved with chemotherapy.

## Contribution

This case highlights a rare presentation of LPL with massive kidney infiltration and its successful treatment.

## Key findings

- The patient had acute kidney injury due to direct tumor infiltration from IgG-secreting LPL.
- Chemotherapy led to both hematological and renal improvements in the patient.

## Abstract

Various factors related to lymphoplasmacytic lymphoma (LPL) can lead to kidney complications; however, LPL‐related kidney complications are not as well‐described as those with multiple myeloma. Here, we report a case of IgG‐secreting LPL presenting with acute kidney injury owing to direct tumor infiltration. Chemotherapy resulted in hematological and renal improvements.

## Linked entities

- **Diseases:** lymphoplasmacytic lymphoma (MONDO:0000432), acute kidney injury (MONDO:0002492)

## Full-text entities

- **Diseases:** tumor (MESH:D009369), acute kidney injury (MESH:D058186), kidney complications (MESH:D007674), LPL (MESH:D008223), multiple myeloma (MESH:D009101)

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12575438/full.md

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Source: https://tomesphere.com/paper/PMC12575438