Synergy between photonics and biological approaches—A review of combination therapies for cancer theranostics
Jacob P. Adams, Luke Pauli, Lin Wang, Trisha Valerio, Coline Furrer, Min Li, Naoko Takebe, Joanne Tuohy, Wei R. Chen
TL;DR
This paper reviews how combining photonics-based therapies with other cancer treatments can improve cancer theranostics.
Contribution
The paper provides a comprehensive review of combination therapies involving phototherapy and other modalities for enhanced cancer treatment.
Findings
Phototherapy alone has limitations in treating metastatic cancers and lacks systemic effects.
Combining phototherapy with immunotherapy and nanomedicine can enhance therapeutic outcomes.
Photonics-based theranostics enable simultaneous diagnosis and treatment.
Abstract
Cancer therapies have evolved considerably over the past several decades. Physical interactions, particularly through phototherapy as a new class of treatment modality, have become widely used. Phototherapy utilizes light to combat cancer by generating heat (photothermal therapy), reactive oxygen species (photodynamic therapy), or photochemical internalization, to kill targeted cells. While these therapies have shown promise in pre-clinical studies, they have demonstrated limitations in clinical cancer treatment. Primarily, while phototherapies excel in eliminating primary tumors, they often fail to provide systemic effects, particularly when treating metastatic cancers, in addition to certain undesirable side effects. Phototherapy has been combined with immunotherapy, nanomedicine, and other cancer therapies to overcome specific weaknesses and enhance the therapeutic benefits of…
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Taxonomy
TopicsNanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Cancer Research and Treatments