# Anesthetic Considerations in Pediatric Corneal Neurotization: A Case Report

**Authors:** José Enrique Díaz Vázquez, Mauricio Muleiro-Alvarez, Alejandra Botero-Benítez, María Alejandra Juárez Tirado, Javier Burgos Cárdenas, Neyra Xiomara Pérez Garcés, Tania Albavera-Giles, Alexandro Aguilera, Nicolás Kahuam-López, Arturo Ramirez-Miranda, Guillermo Raul Vera-Duarte

PMC · DOI: 10.7759/cureus.93566 · 2025-09-30

## TL;DR

This case report discusses anesthetic strategies for a six-year-old child undergoing corneal neurotization surgery to treat congenital corneal anesthesia.

## Contribution

The paper provides a detailed account of anesthetic management in a rare pediatric corneal neurotization case.

## Key findings

- Anesthetic care focused on anxiety reduction, airway safety, and multimodal analgesia.
- The procedure was uneventful with stable hemodynamics and effective postoperative pain control.
- Tailored anesthetic strategies are crucial for pediatric neurotization procedures.

## Abstract

Congenital corneal anesthesia (CCA) is a rare pediatric disorder characterized by absent or markedly reduced corneal sensation, predisposing to neurotrophic keratopathy and vision-threatening complications. Corneal neurotization has emerged as a surgical option to restore corneal innervation, but anesthetic considerations in pediatric cases remain scarcely reported. We present the anesthetic management of a six-year-old female child with CCA and recurrent herpetic keratitis following deep anterior lamellar keratoplasty, who underwent indirect corneal neurotization with a sural nerve graft. Anesthetic care focused on preoperative anxiety reduction, airway safety, multimodal analgesia, and limited neuromuscular blockade to facilitate intraoperative neuromonitoring. Standard monitoring included electrocardiography, non-invasive blood pressure, pulse oximetry, capnography, temperature, and ulnar nerve twitch assessment. Perioperative antiviral prophylaxis (oral acyclovir) was maintained, and ondansetron was administered for PONV prophylaxis. The four-hour procedure was uneventful, with stable hemodynamics and adequate postoperative pain control. Pain was assessed using the FLACC (Face, Legs, Activity, Cry, Consolability) scale, which remained at a level of <3/10 throughout the first 24 hours. This report highlights the importance of tailored anesthetic strategies in pediatric neurotization procedures, balancing surgical requirements with age-specific physiological considerations.

## Linked entities

- **Chemicals:** acyclovir (PubChem CID 135398513), ondansetron (PubChem CID 4595)
- **Diseases:** neurotrophic keratopathy (MONDO:0015290), herpetic keratitis (MONDO:0015288)
- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Diseases:** CCA (MESH:D008305), Pain (MESH:D010146), neuromuscular blockade (MESH:D020879), herpetic keratitis (MESH:D016849), anxiety (MESH:D001007), neurotrophic keratopathy (MESH:C562399)
- **Chemicals:** acyclovir (MESH:D000212), ondansetron (MESH:D017294)

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12574607/full.md

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Source: https://tomesphere.com/paper/PMC12574607