# The maternal and child mortality in the Middle East and North Africa between 2000 and 2020: the role of health financing

**Authors:** Tianjiao Gao, Marwa Farag, Guohong Li, Wu Zeng

PMC · DOI: 10.1186/s41256-025-00459-1 · 2025-10-30

## TL;DR

This study examines how health financing affects maternal and child mortality rates in the Middle East and North Africa from 2000 to 2020.

## Contribution

The study identifies specific health financing factors and socioeconomic indicators that influence maternal and child mortality trends in the MENA region.

## Key findings

- Middle-income countries in the MENA region showed the highest reduction rates in maternal and child mortality.
- GDP per capita and health expenditure per capita had significant negative associations with mortality rates.
- Fragility and low-income status were linked to higher mortality rates and slower progress.

## Abstract

Improving maternal and child health (MCH) outcomes is a critical agenda item in global development. Health financing factors play a crucial role in affecting MCH outcomes, which vary substantially in the Middle East and North Africa (MENA) region. This study aims to examine the trends in maternal mortality rate (MMR), infant mortality rate (IMR), and under-5 mortality rate (U5MR) in the MENA region and the potential impact of health financing factors on them.

We compiled data on MCH mortalities and potential determinants, including health financing factors, for all countries in the MENA region from 2000 to 2020. We calculated the growth rate of mortalities and explored the association between mortality rates and potential determinants using fixed-effects models.

The average MMR, IMR, and U5MR showed an overall descending trend in the region. Middle-income countries experienced the highest reduction rates (3.46–3.73%), followed by high-income countries (2.97–3.02%) and then low-income countries (0.33–0.92%). Gross domestic product (GDP) per capita, current health expenditure (CHE) per capita, urbanization, and fragility were consistently associated with all three mortality rates (p < 0.05). GDP elasticity of MMR, IMR, and U5MR was estimated at − 0.121, − 0.076, and − 0.138, respectively, while corresponding CHE elasticity was − 0.319, − 0.275, and − 0.225, with a larger magnitude. Fragility was positively associated with higher MMR, IMR, and U5MR. Additionally, government health spending, air pollution, and immigration were associated with MMR, but not with IMR and U5MR.

Low-income countries in the MENA region, with the highest mortality rates, face greater challenges in reducing MCH mortality rates, necessitating tailored interventions to expand evidence-based MCH services and/or reinforce their effectiveness. Total investment in health plays a critical role in reducing mortality rates. Efforts to build a sustainable health financing system are key to improving MCH outcomes. Besides, endeavors to address broader socioeconomic factors and political stability should be prioritized in countries with major concerns of poverty and conflict.

The online version contains supplementary material available at 10.1186/s41256-025-00459-1.

## Full-text entities

- **Genes:** ENAH (ENAH actin regulator) [NCBI Gene 55740] {aka ENA, MENA, NDPP1}, WASH6P (WASP family homolog 6, pseudogene) [NCBI Gene 653440] {aka CXYorf1, FAM39A, WASH}, PMCH (pro-melanin concentrating hormone) [NCBI Gene 5367] {aka MCH, ppMCH}
- **Diseases:** communicable diseases (MESH:D003141), WDI (MESH:D002658), under-5 (MESH:D008232), mental disorders (MESH:D001523), hypertensive disorders (MESH:D006973), CHE (OMIM:603663), depression (MESH:D003866), gestational diabetes (MESH:D016640), respiratory disease (MESH:D012140), placental abruption (MESH:D000037), death (MESH:D003643), falling ill (MESH:C537863)
- **Chemicals:** CO2 (MESH:D002245)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12573875/full.md

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Source: https://tomesphere.com/paper/PMC12573875