# Association between polycystic ovary syndrome and systemic immune inflammation index and other inflammation markers; a case-control study

## TL;DR

This study found that women with polycystic ovary syndrome have higher levels of inflammation markers, including a new marker called the systemic immune inflammation index.

## Contribution

The study introduces the systemic immune inflammation index as a new marker for inflammation in polycystic ovary syndrome patients.

## Key findings

- PCOS patients had significantly higher hemoglobin, white blood cell, platelet, neutrophil, and lymphocyte levels compared to controls.
- The systemic immune inflammation index was notably elevated in PCOS patients.
- These findings suggest a link between PCOS and systemic inflammation.

## Abstract

The aim of this study was,to determine the relationship between the systemic immune inflammation index-, which is a new inflammatory marker, and other inflammatory markers in patients with polycystic ovary syndrome.

This case-control study was conducted by exaimining patients who presented at the Gynecology and Obstetrics Outpatient Clinic of Derince Training and Research Hospital between 2018-2022. Inflammatory markers were compared in hemogram parameters of 180 patients with polycystic ovary syndrome and 178 control group subjects. The two groups were compared in respect of hemoglobin(Hb), white blood cell (Wbc), platelet (Plt), neutrophil (Neu), lymphocyte (Ly), red cell distribution width(RDW), main platelet volume (MPV), platelet distribution width (PDW), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and systemic immune inflammation index (SII)values.

The hemoglobin, white blood cell, platelet, neutrophil, lymphocyte,neutrophil lymphocyte ratio,and systemic immune inflammation index values were determined to be statistically significantly higher in PCOS patients than in the control group.

Elevated values of inflammatory markers can be detected in patients with polycystic ovary syndrome,- supporting the presence of inflammation.