Association of Triglyceride–Glucose Index With Different Cardiovascular Diseases in Non‐Diabetic Hypertension

TL;DR

The study finds that a higher triglyceride–glucose index is linked to increased risk of various cardiovascular diseases in non-diabetic hypertension patients.

Contribution

This study is the first to explore the TyG index's association with multiple cardiovascular diseases in non-diabetic hypertensive individuals.

Findings

A higher TyG index is significantly associated with increased risk of cardiovascular disease death, heart failure, and stroke.

The TyG index shows a consistent positive correlation with myocardial infarction and peripheral arterial disease in non-diabetic hypertension patients.

Abstract

This research intends to explore the association of the triglyceride‐glucose (TyG) index with cardiovascular disease (CVD) death, stroke, myocardial infarction (MI), heart failure (HF) and peripheral arterial disease (PAD) in non‐diabetic hypertension. This post hoc analysis uses data from a large‐scale randomised controlled trial (RCT) study—Systolic Blood Pressure Intervention Trial (SPRINT), and we used Cox proportional hazards regression to explore the relationship between TyG and different CVDs. This longitudinal analysis of 9323 participants revealed a significant positive association between the TyG index and CVD death (HR 1.91, 95% CI 1.34, 2.73), HF (HR 1.43, 95% CI 1.05, 1.94), MI (HR 1.30, 95% CI 1.00, 1.69), stroke (HR 1.60, 95% CI 1.16, 2.21) and PAD (HR 1.78, 95% CI 1.30, 2.44). This positive correlation was consistently observed across different subgroups. Trend tests were significant for CVD death, heart failure, MI, stroke and PAD (p < 0.05). In non‐diabetic hypertensive patients, a higher TyG index was associated with a higher risk of CVD (CVD death, stroke, HF, MI, PAD).

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