# Risk Factor Analysis of Death in Patients With Hepatic Cellular Carcinoma After Radical Operation: A Consecutive Cohort of 433 Patients

## TL;DR

This study identifies risk factors affecting survival and recurrence in patients with hepatic cellular carcinoma after surgery, aiming to improve prognosis prediction and patient outcomes.

## Contribution

The study identifies tumor number, microvascular invasion, AST, and GGT as key predictors of both disease-free and overall survival in HCC patients post-surgery.

## Key findings

- Tumor number, microvascular invasion, AST, and GGT are independent risk factors for both DFS and OS in HCC patients.
- Multivariable analysis identified several clinical and pathological factors significantly associated with survival outcomes.
- Early screening of patients with these risk factors may help prevent tumor recurrence and improve survival.

## Abstract

No matter what kind of radical operation, the recurrence and metastasis of tumor will seriously affect the postoperative long‐term effect, and hinder the survival of hepatic cellular carcinoma (HCC) patients. This study aims to explore the relevant risk factors through multivariable analysis, to provide basis for the screening of prognostic factors of HCC and the prevention of tumor related events.

433 patients with HCC after radical operation were involved in this study. The general clinical data, pathological data and laboratory indicators of patients were analyzed through univariate and multivariable analysis. Finally, the independent risk factors of disease free survival (DFS) and overall survival (OS) in patients were screened out.

The 1‐, 3‐, and 5‐year DFS rates were 70.67%, 49.65% and 40.65%, while the 1‐, 3‐, and 5‐year OS rates were 90.30%, 79.68% and 70.67%, respectively. Multivariable analysis showed that tumor number, microvascular invasion, thickness of resection margin, AFP, AST and GGT were the independent risk factors of DFS, while PS score, tumor number, maximal tumor size, ES classification, microvascular invasion, AST and GGT were the independent risk factors of OS (p < 0.05).

Tumor number, microvascular invasion, AST and GGT are correlated with both shorter DFS and OS, which means they can be considered as predictors of the prognosis and recurrence in patients with HCC after radical operation. Patients with these risk factors should be screened in time, which is of great significance to prevent tumor related events and improve survival.