# High Risk, Low Key: The New Face of Drug Use

**Authors:** James R. Burmeister, John K. Jung

PMC · DOI: 10.1177/29768357251389682 · Substance Use : Research and Treatment · 2025-10-26

## TL;DR

Modern drug use is becoming more subtle and socially accepted, often disguised as wellness, requiring new approaches to address hidden risks.

## Contribution

The paper introduces a new framework to address the rebranded and concealed nature of modern drug use trends.

## Key findings

- Substances like THC and psilocybin are marketed as wellness products, leading to normalized use.
- Digital platforms contribute to the fentanyl crisis by enabling counterfeit pill distribution.
- Legal gray-area drugs like kratom and nitrous oxide pose serious health risks due to easy access.

## Abstract

In today’s rapidly evolving substance use landscape, the traditional image of drug consumption is being replaced by a subtler, more socially accepted aesthetic. High Risk, Low Key: The New Face of Drug Use explores how modern intoxicants, from THC-infused beverages to microdosed psilocybin and nitrous oxide canisters, are increasingly marketed as wellness products rather than recreational drugs. This shift, driven by cultural, technological, and mental health trends, has led to the normalization and concealment of daily drug use, especially among youth. Cannabis, once emblematic of rebellion, is now branded as organic and therapeutic, despite rising potency and associated risks. Meanwhile, legal gray-area substances like kratom and nitrous oxide offer easily accessible highs with potentially serious health consequences. The rise of self-medication, fueled by online platforms and a mental health crisis, further blurs the line between therapy and abuse. Digital platforms now serve as decentralized drug markets, contributing to the fentanyl crisis through counterfeit pills. This article calls for a new framework to address these trends, one that includes updated education, regulation, and clinical tools responsive to a generation navigating a silent, rebranded drug crisis.

## Linked entities

- **Chemicals:** THC (PubChem CID 16078), psilocybin (PubChem CID 10624), fentanyl (PubChem CID 3345), nitrous oxide (PubChem CID 948)

## Full-text entities

- **Chemicals:** psilocybin (MESH:D011562), fentanyl (MESH:D005283), THC (MESH:D013759), nitrous oxide (MESH:D009609)

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12572590/full.md

## References

30 references — full list in the complete paper: https://tomesphere.com/paper/PMC12572590/full.md

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Source: https://tomesphere.com/paper/PMC12572590