# Aminocatalytic 1,6-Addition of 2‑Benzyl-3-furaldehyde to 3‑Cyano-4-styrylcoumarins: A Dearomative Approach for the Synthesis of Furan–Coumarin Hybrids

## TL;DR

This paper presents a new method to create furan-coumarin hybrids using aminocatalysis and dearomatization.

## Contribution

A novel aminocatalytic 1,6-addition method for synthesizing furan–coumarin hybrids via dearomatization.

## Key findings

- A catalytic system with an aminocatalyst and acidic cocatalyst enables efficient 1,6-addition.
- The method works with a wide range of substrates to form furan–coumarin hybrids.
- Temporary dearomatization of 2-benzyl-3-furaldehyde is key to the reaction pathway.

## Abstract

In the manuscript,
the application of temporary dearomatization
of 2-benzyl-3-furaldehyde under aminocatalytic conditions in a 1,6-addition
pathway is described. In such reaction setup catalytically generated
dienamine derived from heteroaromatic aldehydes reacts with coumarin
derivatives in 1,6-addition. Developed approach utilizes a catalytic
system consisting of an aminocatalyst and an acidic cocatalyst, which
is crucial for the reaction efficiency. The reaction displays a wide
substrate scope generating target products containing furan and coumarin
moieties.